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Thread: ketamin/xylazine?

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  1. #1
    Junior Member
    Join Date
    Oct 2009
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    15

    Default ketamin/xylazine?

    Dear sir,
    im using ketamine/xylazine for 2vo surgery in male sprogue dawely rat, I
    lose a lot of my rats post-operatively, the problem how much time dose the
    rat require to have adequate temperature(isnt it within 4-5 hours
    postoperatively), and about the fluid supplement is recommended to give all
    the rats 10 ml normal saline.

  2. #2
    Junior Member
    Join Date
    Oct 2009
    Posts
    15

    Default

    I'm not sure what 2vo refers to, but I've done quite a few surgeries on
    rats. However, the best person to consult in the matter would be a
    Veterinary Technician or a Veterinarian if you have access to one.

    Rats should be able to push themselves up (and have control over their body
    temperature) about 4-5 hours after the last dose of anesthesia. And 5-10ml
    of Lactated Ringer's saline (0.9% NaCl) is also typical.

    If your rats aren't waking up at all, some things to consider in your case
    could be:

    Anesthisia
    -Are the rats receiving the correct dose of anesthesia before surgery
    (should be about 40-80mg/kg Ketamine with 5-10mg/kg Xylazine)?
    -And if your surgery lasts more than an hour, are they receiving the correct
    maintainance doses (maintanance doses are lower, usually the inital volume
    multiplied by about 0.38)?

    Temperature Maintanance
    -Are they kept warm (but not too warm) during the surgery?

    Blood loss
    -Are the rats bleeding a lot during your surgery, and is the bleeding
    stopped before the end of surgery?

  3. #3

    Default

    The most widely used dose of Ketamine/Xylazine for mouse surgery is 100 mg/kg and 10 mg/kg body weight, respectively (Flecknell 1993). Duration of the effect may be extended by increasing the proportion of Xylazine or by an additional dose of Ketamine.

    Thanks in advance,
    Stephen

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