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Thread: vGLU

  1. #1
    Junior Member
    Join Date
    Jan 2015

    Default vGLU

    Hi all,
    I read an article on "nature biotechnology" journal titled "Medial ganglionic eminence–like cells derived from human embryonic stem cells correct learning and memory deficits" (easy to find, just search in nature, pubmed or google scholar).

    in the article there's this sentence: "Analysis of synapses revealed that human (STEM121+) GABA+ neurons in both types of graft were surrounded by vGLU+ punctae in the cell bodies and fibers, suggesting potential glutamatergic inputs into grafted GABA+ neurons."

    I looked all over the web to find out what exactly is vGLU. Obviously it has something to do with glutamate so the only thing that came to my mind is VGLUT - vesicular glutamate transporter, but I can't be sure and I have big doubts since vGLU is not a common name of vesicular glutamate transporter. In addition, as far as I know, vesicular glutamate transporters are characteristics of glutamatergic neurons and are found in glutamaterfic neurons' cell bodies and axons, so why were they found around GABAergic neurons cell bodies and fibers as stated above? this another thing that strengthen my doubts.

    I really need that missing piece of the puzzle since I'm about to give a lecture on this article in a few days.
    If anyone have a clue - please help..!

    Thanks in advance!

  2. #2

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